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D-Lin-MC3-DMA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
D-Lin-MC3-DMA图片
CAS NO:1224606-06-7
规格:98%
分子量:642.09
包装与价格:
包装价格(元)
200mg电议
500mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
D-Lin-MC3-DMA 是一种阳离子脂质体, 是一种有效的递送 siRNA 载体。目前广泛应用于肿瘤基因治疗研究中。
CAS:1224606-06-7
分子式:C43H79NO2
分子量:642.09
纯度:98%
存储:Store at -20°C

Background:

D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle.



Lipid nanoparticles (LNPs) containing distearoylphosphatidlycholine (DSPC), and ionizableamino-lipids such as dilinoleylmethyl-4-dimethylaminobutyrate (DLin-MC3-DMA) are potent siRNA delivery vehicles in vivo. LNP-siRNA systems optimize to achieve maximum gene silencing potency in hepatocytesfollowing IV administration in mice contain DLin-MC3-DMA (MC3), DSPC, cholesterol and a polyethyleneglycol (PEG)-lipid at mole ratios of 50/10/38.5/1.5. DLin-MC3-DMA exhibits an optimized pKa value that leads to dramatically enhanced potency[1].


[1]. Kulkarni JA, et al. Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA. Nanomedicine. 2017 May;13(4):1377-1387.