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IM-54
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
IM-54图片
CAS NO:861891-50-1
规格:98%
分子量:325.4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
IM-54 is an indolylmaleimide derivative which, at 1 μM, inhibits necrotic cell death induced by H2O2 in promyelocytic leukemia HL-60 cells.
CAS:861891-50-1
分子式:C19H23N3O2
分子量:325.4
纯度:98%
存储:Store at -20°C

Background:

IM-54 is an indolylmaleimide derivative which, at 1 μM, inhibits necrotic cell death induced by H2O2 in promyelocytic leukemia HL-60 cells. It does not prevent etoposide-induced apoptosis and does not inhibit protein kinase C or S6 kinase [1]


Reference:
[1]. Dodo, K., Katoh, M., Shimizu, T., et al. Inhibition of hydrogen peroxide-induced necrotic cell death with 3-amino-2-indolylmaleimide derivatives. Bioorganic & Medicinal Chemistry Letters 15(12), 3114-3118 (2005).