GRGDSPK是一种含有精氨酸-甘氨酸-天冬氨酸(RGD)的多肽，能够抑制RGD介导的整合蛋白和细胞外基质分子的附着。
CAS：111119-28-9
分子式：C28H49N11O11
分子量：715.76
纯度：98%
存储：Store at -20°C

Background:

GRGDSPK is an inhibitory peptide for RGD-mediated adhesion between integrin and extracellular matrix molecules.

GRGDSPK inhibits the adhesion of Rat PDL cells[1]. RGD-containing (GRGDSPK, 1.5 mM, 1.0 mM, and 0.5 mM) and RGD-mod-ified peptides impair the ability of sperm to fertilizebovine oocytes, illustrated by a reduction in cleavage in a dose-dependent manner[2].

[1]. Hatakeyama J, et al. Proliferation and adhesion of periodontal ligament cells on synthetic biominerals. Oral Dis. 2007 Sep;13(5):500-6. [2]. Sessions BR, et al. Effects of amino acid substitutions in and around the arginine-glycine-aspartic acid (RGD) sequence on fertilization and parthenogenetic development in mature bovine oocytes. Mol Reprod Dev. 2006 May;73(5):651-7.