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MK-447
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MK-447图片
CAS NO:58456-91-0
规格:98%
分子量:305.16
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
MK-447是一种自由基清除剂,同时为非甾体类抗炎剂,能够增强PGH2等其他前列腺素(prostaglandin)的形成。
CAS:58456-91-0
分子式:C11H16INO
分子量:305.16
纯度:98%
存储:Store at -20°C

Background:

MK-447 is a free radical scavenger, also a nonsteroidal antiinflammatory agent, and enhances the formation of the endoperoxide, PGH2, and other prostaglandins.


MK-447 is a free radical scavenger, reduces the accumulation of the endoperoxide, PGG2 and also enhances the formation of the endoperoxide, PGH2, and other prostaglandins[1]. MK-447 (100 μM) increases the amounts of prostaglandin I2 (PGI2). MK-447 also accelerates endogenous PGI2 generation in the isolated rat aorta[2].


MK-447 (20 and 50 mg/kg, p.o.) blocks gastric acid secretion in the 4 hour pylorus ligated rats, but shows no effect on gastric secretion of pepsin. MK-447 (5, 10, 20 and 40 mg/kg, p.o.) dose-dependently decreases acid output in dogs[1].


[1]. Shriver DA, et al. The gastric antisecretory and antiulcer activity of MK-447, an enhancer of prostaglandin synthesis. Life Sci. 1980 Dec 22-29;27(25-26):2483-7. [2]. Harada Y, et al. Acceleration of endogeneous PGI2 generation from isolated rat aortae by MK-447. Jpn J Pharmacol. 1981 Oct;31(5):845-8.