Background:

Alexamorelin is a new synthetic heptapeptide which inhibits GHS binding in vitro.

Alexamorelin shows the same GH-releasing activity as hexapeptide hexarelin (HEX). On the other hand, Alexamorelin seems endowed with an ACTH-releasing activity more marked than that of HEX[1].

[1]. Broglio F, et al. Endocrine activities of alexamorelin (Ala-His-d-2-methyl-Trp-Ala-Trp-d-Phe-Lys-NH2), a synthetic GH secretagogue, in humans. Eur J Endocrinol. 2000 Sep;143(3):419-25.