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PKR-IN-2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PKR-IN-2图片
CAS NO:1628428-01-2
规格:98%
分子量:468.57
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
PKR-IN-2是一种丙酮酸激酶(PKR)激活剂。
CAS:1628428-01-2
分子式:C24H28N4O4S
分子量:468.57
纯度:98%
存储:Store at -20°C

Background:

PKR-IN-2 is a pyruvate kinase (PKR) activator, extracted from patent WO2014139144A1, compound 160, has an IC50 of<100 nM for. PKR (R510Q), PKR (R532W), PKR (WT), and PKR (WT Cell Based).IC50 value:<100 nM (AC50)Target: PKR




[1]. Popovici-Muller, et al. Preparation of N-(piperidinecarbonylphenyl) sulfonamide compounds as pyruvate kinase modulators. From PCT Int. Appl. (2014), WO2014139144A1 20140918. [2]. Cianchetta Giovanni, et al. Preparation of aroylpiperidines, particularly arysulfonylamino and heteroarylsulfonylamino substituted, as pyruvate kinase PKM2 modulators useful in the treatment of cancer and compositions containing them. From PCT Int. Appl.