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AGN 205728
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AGN 205728图片
CAS NO:859498-05-8
规格:98%
分子量:437.53
包装与价格:
包装价格(元)
250mg电议
500mg电议

产品介绍
AGN 205728是选择性RARγ拮抗剂,Ki/IC95分别为3 nM/ 0.6 nM,对RARα和RARβ无抑制性。
CAS:859498-05-8
分子式:C29H27NO3
分子量:437.53
纯度:98%
存储:Store at -20°C

Background:

AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ.IC50 value: 3 nM/ 0.6 nM(Ki/IC95)Target: RARγ antagonistMore information can be found in the following patent, Compound 7a.Preparation of disubstituted chalcone oximes having RARγ retinoid receptor antagonist activityBy Tsang, Kwok Yin; Sinha, Santosh; Liu, Xiaoxia; Bhat, Smita; Chandraratna, Roshantha A.From PCT Int. Appl. (2005), WO 2005066115 A2 20050721.




[1]. Tsang, Kwok Yin, et al. Preparation of disubstituted chalcone oximes having RARγ retinoid receptor antagonist activity. Appl. (2005), WO 2005066115 A2 20050721.