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Annonacin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Annonacin图片
CAS NO:111035-65-5
规格:98%
分子量:596.9
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
Annonacin is a potent and lipophilic acetogenin from A.
CAS:111035-65-5
分子式:C35H64O7
分子量:596.9
纯度:98%
存储:Store at -20°C

Background:

Annonacin is a potent and lipophilic acetogenin from A. muricata that inhibits mitochondrial complex I (IC50 = 54.8 nM)., Annonacin induces ATP depletion, tau pathologies, and dopaminergic cell death in rats (EC50s = 134, 44.1, and 60.8 nM, respectively). Quantities of annonacin in the fruit and teas made from leaves of A. muricata are such that a cumulative dose sufficient to induce murine neurodegeneration can be attained in humans by regular consumption within one year. This implicates annonacin in the etiology of taupathologies identified in regions of A. muricata consumption. Annonacin also reduces cell survival (ED50 = 0.31 uM in MCF-7 cells) and decreases MCF-7 xenograft tumor size in nude mice at a dose of 50 mg/kg per day.