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16(R)-AFP 07(free acid)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
16(R)-AFP 07(free acid)图片
CAS NO:773825-80-2
规格:98%
分子量:412.5
包装与价格:
包装价格(元)
5mg电议
500ug电议
1mg电议

产品介绍
Prostaglandin I2 is an unstable prostanoid which, through the 'I prostanoid' (IP) receptor, inhibits platelet aggregation and promotes vasodilatation in pulmonary vascular beds.
CAS:773825-80-2
分子式:C22H30F2O5
分子量:412.5
纯度:98%
存储:Store at -20°C

Background:

Prostaglandin I2 is an unstable prostanoid which, through the ’I prostanoid’ (IP) receptor, inhibits platelet aggregation and promotes vasodilatation in pulmonary vascular beds. AFP 07 is a 7,7-difluoroprostacyclin derivative that acts as a selective and highly potent agonist for the IP receptor (Ki = 0.561 nM). AFP 07 shows weaker affinity for EP receptors, with Ki values >100 nM for EP1-3 and >10 nM for EP4. 16(R)-AFP 07 is an epimer of AFP 07. Its biological properties, particularly through the IP and EP receptors, remain to be evaluated.