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(+)-Penbutolol((R)-Penbutolol)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(+)-Penbutolol((R)-Penbutolol)图片
CAS NO:38363-41-6
规格:98%
分子量:291.43
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
(+)-Penbutolol是一种β肾上腺素拮抗剂,其IC50值为0.74μM.(+)-Penbutolol也是(-)-penbutolol的光学异构体,具有阻断Na+通道的作用。
CAS:38363-41-6
分子式:C18H29NO2
分子量:291.43
纯度:98%
存储:Store at -20°C

Background:

(+)-Penbutolol is a β-adrenoceptor antagonist, with an IC50 of 0.74 μM[1]. (+)-Penbutolol is an optical isomer of l-penbutolol with Na+ channel-blocking action[2].


(+)-penbutolol on the [Ca2+]i-increase induced by LPC is concentration-dependent[1].(+)-penbutolol inhibits the rounding of cells dose dependently (8±4%, 56±4% and 66±2% at the concentrations of 10-6 M, 5×10-6 M and 10-5 M, respectively)[2].



[1]. Chen M, et al. Effects of beta-adrenoceptor antagonists on Ca(2+)-overload induced by lysophosphatidylcholine in rat isolated cardiomyocytes. Br J Pharmacol. 1996 Jun;118(4):865-70. [2]. Hashizume H, et al. Effects of antiischemic drugs on veratridine-induced hypercontracture in rat cardiac myocytes. Eur J Pharmacol. 1994 Dec 12;271(1):1-8.