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Tafenoquine Succinate(WR 238605(Succinate))
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tafenoquine Succinate(WR 238605(Succinate))图片
CAS NO:106635-81-8
规格:98%
分子量:581.58
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
TafenoquineSuccinate(WR238605Succinate)是一种8-氨基喹啉。Tafenoquine作为抗疟疾预防剂。
CAS:106635-81-8
分子式:C28H34F3N3O7
分子量:581.58
纯度:98%
存储:Store at -20°C

Background:

Tafenoquine Succinate (WR 238605 Succinate) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent[1].



Tafenoquine exhibits no anti-malarial activity in CYP 2D knock-out mice when dosed at their ED100 values (3 mg/kg) established in WT mice. Tafenoquine anti-malarial activity is partially restored in humanized/CYP 2D6 knock-in mice when tested at two times its ED100 (6 mg/kg)[1].


[1]. Marcsisin SR, et al. Tafenoquine and NPC-1161B require CYP 2D metabolism for anti-malarial activity: implications for the 8-aminoquinoline class of anti-malarial compounds. Malar J. 2014 Jan 3;13:2.