ACX-362E 是一种口服有效的 DNA 聚合酶 IIIC (pol IIIC) 的抑制剂，作为抗菌剂用于抗革兰氏阳性菌感染，对 C. difficile 的 MIC50 值为 2 μg/mL。ACX-362E 在体内和体外均表现出高效、广谱的抗 C. difficile 活性。
CAS：1275582-97-2
分子式：C18H20Cl2N6O2
分子量：423.3
纯度：98%
存储：Store at -20°C

Background:

ACX-362E is an orally available DNA polymerase IIIC (pol IIIC) inhibitor, acts as an antimicrobial agent to treat Gram-positive infections, with a MIC50 of 2 μg/mL for C. difficile. ACX-362E displays very potent in vitro and in vivo activities against broad spectrum of C. difficile pathogens[1]. MIC50: 2 μg/mL (C. difficile)[1]

[1]. Xu WC, et al. Discovery and development of DNA polymerase IIIC inhibitors to treat Gram-positive infections. Bioorg Med Chem. 2019 Jun 11. pii: S0968-0896(19)30663-7.