Background:

DSP-2230 is a selective Nav1.7/Nav1.8 blocker[1][2]. Nav1.7/Nav1.8[1]

[1]. Bagal SK, et al. Voltage gated sodium channels as drug discovery targets. Channels (Austin). 2015;9(6):360-6. [2]. Sara Sabina Hadida-Ruah, et al. Sulfonamides as modulators of sodium channels.