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Penicillic Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Penicillic Acid图片
CAS NO:90-65-3
规格:98%
分子量:170.2
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
mycotoxin
CAS:90-65-3
分子式:C8H10O4
分子量:170.2
纯度:98%
存储:Store at -20°C

Background:

Penicillic acid is synthesized by a large number of fungi, such as P. puberulum, Penicillium stoloniferum, P. eye/opium Penicillium martensii, Penicillium thomii. The synthesis of this secondary metabolite has little or no taxonomic significance [1].


In vitro: The compound was active primarily against gram-negative bacteria, and it was also active against some gram-positive species. It showed limited antihelminthic properties but did affect the growth of oat seed coleoptiles by interference with the respiratory process. Penicillic acid has proven to be too toxic for use in therapy [1]. Penicillic acid (80 μM) inhibited bacterial quorum sensing communication in P. aeruginosa by selectively repressing various virulence factor and other quorum sensing-regulated genes [2]. In Burkitt’s lymphoma Raji cells, penicillic acid exihibited an inhibitory effect on Fas-mediated apoptosis at 100-200 μM by targeting caspase-8 activity [3].


In vivo: The LDso (subcutaneous injection) for mice is 100 mg/kg. Subcutaneous injection of 1.0 mg/dose twice weekly produced transplantable tumors after 64 weeks in all rats surviving treatment. In addition, a dose at 0.1 mg initiated tumor development [1].


参考文献:
[1] Ciegler A, Detroy R W, Lillehoj E B.  Patulin, penicillic acid, and other carcinogenic lactones[J]. Microbial toxins, 1971, 6: 409-434.
[2] Rasmussen T B, Skindersoe M E, Bjarnsholt T, et al.  Identity and effects of quorum-sensing inhibitors produced by Penicillium species[J]. Microbiology, 2005, 151(5): 1325-1340.
[3] Bando M, Hasegawa M, Tsuboi Y, et al.  The mycotoxin penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8 in death-inducing signaling complex[J]. Journal of Biological Chemistry, 2003, 278(8): 5786-5793.