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Irbesartan-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Irbesartan-d4图片
CAS NO:1216883-23-6
规格:98%
分子量:432.6
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
Irbesartan-d4 is intended for use as an internal standard for the quantification of irbesartan by GC- or LC-MS.
CAS:1216883-23-6
分子式:C25H24D4N6O
分子量:432.6
纯度:98%
存储:Store at -20°C

Background:

Irbesartan-d4 is intended for use as an internal standard for the quantification of irbesartan by GC- or LC-MS. Irbesartan is an antagonist of the angiotensin II type 1 (AT1) receptor (Ki = 1.3 nM). It is an insurmountable antagonist of AT1, as its antagonism cannot be overcome by increasing concentrations of angiotensin II. Irbesartan (3, 10, and 30 mg/kg) reduces blood pressure in stroke-prone spontaneously hypertensive rats and increases survival of SPSH rats fed a high-salt low-protein diet. It also reduces plaque formation, collagen content, as well as the increased expression of the AT1 receptor, PDGF-b, MCP-1, and VCAM-1 in a model of diabetes-induced atherosclerosis using apolipoprotein E (ApoE) knockout mice with diabetes induced by streptozotocin . Formulations containing irbesartan have been used, alone and in combination with diuretics, in the treatment of hypertension.