5-cis Carbaprostacyclin is a stable analog of PGI2 and an isomer of carbaprostacyclin.
CAS：69609-77-4
分子式：C21H34O4
分子量：350.5
纯度：98%
存储：Store at -20°C

Background:

5-cis Carbaprostacyclin is a stable analog of PGI2 and an isomer of carbaprostacyclin. It is a weak inhibitor of human platelet aggregation with an IC50 of 2.8 µM compared to 0.3 µM for carbaprostacyclin. 5-cis Carbaprostacyclin is a much weaker effector of rabbit mesenteric artery relaxation with an EC50 of 104 µM compared to 5.9 µM for carbaprostacyclin. It even antagonizes the adenylate cyclase activation induced by carbaprostacyclin.