C6 NBD ceramide is a biologically active fluorescent analog of short chain, membrane-permeable ceramides.
CAS：94885-02-6
分子式：C30H49N5O6
分子量：575.7
纯度：98%
存储：Store at -20°C

Background:

C6 NBD ceramide is a biologically active fluorescent analog of short chain, membrane-permeable ceramides.1 It is as effective as C6 ceramide in the inhibition of viral glycoprotein transport through the Golgi.[1] C6 NBD ceramide has been used as a fluorescent substrate for the activity of UDP-glucose:ceramide glucosyltransferase and to demonstrate the translocation of glucocerebroside and sphingomyelin from the Golgi to the plasma membrane.[2],[3]

Reference:
[1]. Rosenwald, A.G., and Pagano, R.E. Inhibition of glycoprotein traffic through the secretory pathway by ceramide. J. Biol. Chem. 268(7), 4577-4579 (1993).
[2]. Paul, P., Kamisaka, Y., Marks, D.L., et al. Purification and characterization of UDP-glucose: Ceramide glucosyltransferase from rat liver Golgi membranes. J. Biol. Chem. 271(4), 2287-2293 (1996).
[3]. Lipsky, N.G., and Pagano, R.E. Intracellular translocation of fluorescent sphingolipids in cultured fibroblasts: Endogenously synthesized sphingomyelin and glucocerebroside analogues pass through the golgi apparatus en route to the plasma membrane. J. Cell. Biol. 100(1), 27-34 (1985).