Hydroxy bosentan is an active phase I metabolite of bosentan produced by the cytochrome P450 isoforms CYP3A4 and CYP2C9.
CAS：253688-60-7
分子式：C27H29N5O7S
分子量：567.6
纯度：98%
存储：Store at -20°C

Background:

Hydroxy bosentan is an active phase I metabolite of bosentan produced by the cytochrome P450 isoforms CYP3A4 and CYP2C9. Bosentan is an antagonist of the endothelin receptors type A (Ki = 6.5 nM) and type B (Ki = 340 nM). Up to 20% of the activity of bosentan may be due to the action of hydroxy bosentan because even though it has a lower affinity for endothelin receptors, its concentration is 3-fold higher in plasma.