AVE5688是糖原磷酸化酶(glycogenphosphorylase(GP))抑制剂，抑制兔肌肉糖原磷酸化酶rmGPb和rmGPa的活性，IC50值分别为430nM和915nM，Kd值分别为170nM和530nM；AVE5688可用于二型糖尿病的研究。
CAS：613260-13-2
分子式：C16H8ClF5N2O5
分子量：438.69
纯度：98%
存储：Store at -20°C

Background:

AVE5688 is an inhibitor of glycogen phosphorylase (GP), with IC50s of 430 nM and 915 nM and Kds of 170 nM and 530 nM for rabbit muscle glycogen phosphorylase (rmGPb and rmGPa, respectively); AVE5688 can be used for the research of type 2 diabetes.

AVE5688 is an inhibitor of glycogen phosphorylase (GP), with IC50s of 430 nM and 915 nM and Kds of 170 nM and 530 nM for rabbit muscle glycogen phosphorylase (rmGPb and rmGPa, respectively)[1].

[1]. Anderka O, et al. Thermodynamic characterization of allosteric glycogen phosphorylase inhibitors. Biochemistry. 2008 Apr 22;47(16):4683-91.