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MDL 19301
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MDL 19301图片
CAS NO:89388-38-5
规格:98%
分子量:279.46
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
MDL19301是一种非甾体抗炎剂。
CAS:89388-38-5
分子式:C15H21NS2
分子量:279.46
纯度:98%
存储:Store at -20°C

Background:

MDL 19301 is a nonsteroidal, anti-inflammatory agent.



Oral administration of MDL 19301 inhibits rat paw edema induced by carrageenan (ED30=4.8 mg/kg) or an Arthus reaction (ED30=8.2 mg/kg p.o.). The oral dose which induces gastric ulceration in 50% of fasted rats is greater than 1,000 mg/kg, demonstrating a more favorable therapeutic ratio than conventional nonsteroidal anti‐inflammatory agents. The anti-inflammatory activity of MDL 19301, but not that of MDL 16,861, is attenuated by co-administration of an inhibitor of drug metabolite (SKF525A). This suggests that MDL 19301 is a prodrug of MDL 16,861 and this phenomenon would explain its lack of ulcerogenicity. Additional anti-inflammatory properties of MDL 19301 include inhibition of carrageenan pleurisy, adjuvant arthritis, and HOAc-induced writhing. Other pharmacological data indicate that MDL 19301 administration results in inhibition of prostaglandin synthesis; inhibition of arachidonic acid-induced, but not prostaglandin-E2-induced, diarrhea in mice; and inhibition of ex vivo arachidonic-acid-induced, but not ADP-induced, rat platelet aggregation. MDL 19301 and MDL 16,861 are unexpectedly weak antipyretic agents in rats[1].


[1]. NS Doherty, et al. Pharmacological properties of MDL 19,301: A novel, nonsteroidal, anti‐inflammatory agent. Drug Dev Res 1989 16(1) 31-44