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Camphor((±)-Camphor)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Camphor((±)-Camphor)图片
CAS NO:76-22-2
包装:100mg
规格:98%
市场价:445元
分子量:152.23

产品介绍
Camphor((±)-Camphor)是一种外用抗感染和抗瘙痒剂,口服有驱风作用。然而,Camphor摄入时有毒。Camphor具有抗病毒,镇咳和抗癌活性。Camphor是一种TRPV3激动剂。
CAS:76-22-2
分子式:C10H16O
分子量:152.23
纯度:98%
存储:Store at -20°C

Background:

Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities[1]. Camphor is a TRPV3 agonist[2].


Camphor induces fibroblast proliferation through the PI3K/AKT and ERK signaling pathways[3].The MTT assay results show that 32.5, 65, 130, and 260 μM Camphor increase fibroblast viability to 108.9±6.6%, 118.6±2.8%, 127.7±4.2%, and 131.6±7.2%, respectively, compared to 0 μM Camphor treatment[3].Camphor (0-260 μM) treatment for 24 hours increases the generation of ROS by up to 17.97% compared to 5.04% in the no-treatment control[3].Camphor (0-260 μM, 24 hours) induces the phosphorylation of PI3K, AKT, ERK, and 4EBP1 in a dose- and time-dependent manner[3].|| Cell Viability Assay[3]||Cell Line:|Primary dermal fibroblast cells|Concentration:|0-260 μM|Incubation Time:|24 hours|Result:|32.5, 65, 130, and 260 μM increased fibroblast viability to 108.9±6.6%, 118.6±2.8%, 127.7±4.2%, and 131.6±7.2%, respectively, compared to 0 μM treatment.|| Western Blot Analysis[3]||Cell Line:|Primary dermal fibroblast cells|Concentration:|0-260 μM|Incubation Time:|24 hours|Result:|Induced the phosphorylation of PI3K, AKT, ERK, and 4EBP1, a repressor of mRNA translation and mTOR substrate, in a dose- and time-dependent manner.



[1]. Chen W, et al. Camphor--a fumigant during the Black Death and a coveted fragrant wood in ancient Egypt and Babylon--a review. Molecules. 2013 May 10;18(5):5434-54. [2]. Billen B, et al. Different ligands of the TRPV3 cation channel cause distinct conformational changes as revealedby intrinsic tryptophan fluorescence quenching. J Biol Chem. 2015 May 15;290(20):12964-74. [3]. Tran TA, et al. Camphor Induces Proliferative and Anti-senescence Activities in Human Primary Dermal Fibroblasts and Inhibits UV-Induced Wrinkle Formation in Mouse Skin. Phytother Res. 2015 Dec;29(12):1917-25.