Adrenomedullin(AM)(22-52),human为肾上腺髓质素(adrenomedullinreceptor)受体拮抗剂，同时在猫后肢血管床中，对降钙素基因相关肽(CGRP)受体也具有拮抗作用。
CAS：159899-65-7
分子式：C159H252N46O48
分子量：3576.04
纯度：98%
存储：Store at -20°C

Background:

Adrenomedullin (AM) (22-52), human is an adrenomedullin receptor antagonist, and also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat.

Adrenomedullin (AM) (22-52), human shows no effect on hindlimb perfusion pressure responses to adrenomedullin (ADM) at 120 nmol. However, Adrenomedullin (AM) (22-52), human selectively and reversibly decreases vasodilator responses to human calcitonin generelated peptide (hCGRP) at 30 nmol, with similar effect to that of CGRP antagonist[1].

[1]. Champion HC, et al. Adrenomedullin-(22-52) antagonizes vasodilator responses to CGRP but not adrenomedullin in the cat. Am J Physiol. 1997 Jan;272(1 Pt 2):R234-42.