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CMS121
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CMS121图片
CAS NO:1353224-53-9
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
理化性质和储存条件

Name: CMS121
CAS#: 1353224-53-9
Chemical Formula: C20H19NO3
Exact Mass: 321.1365
Molecular Weight: 321.376
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Technical InformationSynonym: CMS-121, CMS 121, CMS121
Chemical Name: 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol
InChi Key: OMHNVUCFPJJLKD-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H19NO3/c22-18-10-9-13(11-19(18)23)17-12-20(24-14-5-1-2-6-14)15-7-3-4-8-16(15)21-17/h3-4,7-12,14,22-23H,1-2,5-6H2
SMILES Code: OC1=CC=C(C2=NC3=CC=CC=C3C(OC4CCCC4)=C2)C=C1O
实验参考方法
Target

Acetyl-CoA carboxylase 1 (ACC1)[1]

In VitroCMS-121 (1 μM; 4 hours; HT22 cells) treatment increases the phosphorylation of ACC1 at serine 79. CMS-121 can increase acetyl-CoA in cells[1]. Western Blot Analysis[1] Cell Line: HT22 cells Concentration: 1 μM Incubation Time: 4 hours Result: Increases the phosphorylation of ACC1 at serine 79.
In VivoCMS-121 (~20 mg/kg; oral administration; daily; for 4 months; female SAMP8 mice) treatment reduces cognitive decline as well as metabolic and transcriptional markers of aging in the brain when administered to rapidly aging SAMP8 mice. CMS-121 preserves mitochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism[1]. Animal Model: Female SAMP8 mice (9 months old)[1] Dosage: ~20 mg/kg/day Administration: Oral administration; daily; for 4 months Result: Reduced cognitive decline as well as metabolic and transcriptional markers of aging in the brain.
References

[1]. Elevating acetyl-CoA levels reduces aspects of brain aging. Elife. 2019 Nov 19;8. pii: e47866.

[2]. Chemical modification of the multitarget neuroprotective compound fisetin. J Med Chem. 2012 Jan 12;55(1):378-89.

[3]. Back to the future with phenotypic screening. ACS Chem Neurosci. 2014 Jul 16;5(7):503-13.