6β-hydroxy Dexamethasone is a metabolite of dexamethasone that is more hydrophilic than the parent compound.
CAS：55879-47-5
分子式：C22H29FO6
分子量：408.5
纯度：98%
存储：Store at -20°C

Background:

6β-hydroxy Dexamethasone is a metabolite of dexamethasone that is more hydrophilic than the parent compound. Dexamethasone is metabolized by CYP3A4; therefore, quantification of the dexamethasone metabolites, 6α- and 6β-hydroxy dexamethasone, can be used to determine CYP3A4 enzyme activity in humans., The formation of 6-hydroxy dexamethasone metabolites is species-specific, with hamsters producing the highest amount. In rats, dexamethasone hydroxylation is sex-specific, with male rats producing metabolites in similar ratios to humans and female rats producing fewer hydroxylated metabolites than male rats.

参考文献:
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