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Bis(methylthio)gliotoxin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bis(methylthio)gliotoxin图片
CAS NO:74149-38-5
规格:98%
分子量:356.5
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
Bis(methylthio)gliotoxin is a fungal metabolite originally isolated from G.
CAS:74149-38-5
分子式:C15H20N2O4S2
分子量:356.5
纯度:98%
存储:Store at -20°C

Background:

Bis(methylthio)gliotoxin is a fungal metabolite originally isolated from G. deliquescens that has diverse biological activities. It inhibits PAF- and collagen-induced platelet aggregation in rabbit platelet-rich plasma (IC50s = 8.4 and 84.2 µM, respectively) but has no effect on arachidonic acid- or ADP-induced platelet aggregation (IC50s = >400 µM). Bis(methylthio)gliotoxin inhibits growth of HCT116 colon cancer cells (IC50 = 23.56 µM). It inhibits PAF-induced bronchoconstriction in guinea pigs when administered at a dose of 0.1 mg/kg and is less toxic to mice (LD50 = >500 mg/kg) than gliotoxin . Bis(methylthio)gliotoxin has been used as a serum biomarker in patients infected with invasive aspergillosis.