Most local anesthetics act by abolishing voltage gated sodium channel currents indiscriminately in all populations of neurons.
CAS：22913-17-3
分子式：C11H17N2O.I
分子量：320.2
纯度：98%
存储：Store at -20°C

Background:

Most local anesthetics act by abolishing voltage gated sodium channel currents indiscriminately in all populations of neurons. Selective analgesia through TRPV1-mediated entry of a cationic lidocaine derivative, QX314, was recently reported. CAY10568 is a physically smaller, less hydrophobic version of QX314 designed to be even more permeable to TRPV1 ion channel when activated by agonists such as capsaicin and N-oleoyl dopamine. CAY10568 when given in combination with suitable TRPV1 agonists should produce selective blockade of the pain response while leaving motor, touch, and proprioception intact.