FTI-2153 is a potent and selective farnesyltransferase (FTase) inhibitor, with an IC50 of 1.4 nM and with >3000-fold more potent at blocking H-Ras (IC50, 10 nM) than Rap1A processing. FTI-2153 inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status. FTI-2153 was reported to block bipolar spindle formation and chromosome alignment and causes prometaphase accumulation during mitosis of human lung cancer cells.

纯度：≥98%

CAS：344900-92-1