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RPH-2823
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RPH-2823图片
CAS NO:96558-24-6
规格:98%
分子量:370.41
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
RPH-2823是一种氨苯蝶啶衍生物,具有利尿的作用。
CAS:96558-24-6
分子式:C17H22N8O2
分子量:370.41
纯度:98%
存储:Store at -20°C

Background:

RPH-2823 is a basic triamterene derivative, with diuretic activity.


RPH 2823 induces a dose-dependent decrease in SCC and increase in transepithelial electrical resistance. RPH 2823 influences transepithelial Na+ transport by interacting with the Na+ channel or a regulator site of it within the apical membrane[1].


RPH 2823 (2.5 mumol/kg) can avoid the kaliuresis of 25 mumol/kg furosemide in male Wistar rats. RPH 2823 (1 mg/kg and 5 mg/kg, i.v.) has a terminal elimination half-life of 3 h. About 47% of the given dose are excreted unchanged with urine[2].


[1]. Kipnowski J, et al. Effects of standard diuretics and RPH 2823 on transepithelial Na+ transport in isolated frog skin. Klin Wochenschr. 1986 Aug 15;64(16):750-9. [2]. Priewer H, et al. Pharmacodynamics and pharmacokinetics of the basic triamterene analogue dimethylaminohydroxypropoxytriamterene. Arzneimittelforschung. 1985;35(11):1688-91.