CGP11952是一种三唑基Benzaphenon。CGP11952是一种苯二氮卓类(benzodiazepine)衍生物。
CAS：64078-09-7
分子式：C21H21Cl2N5O2
分子量：446.33
纯度：98%
存储：Store at -20°C

Background:

CGP11952 is a triazolyl-Benzaphenon resembling the benzodiazepines in its pharmacological action. CGP11952 is an experimental benzodiazepine derivative.

CGP11952 (CGP 11952) is a triazolyl-Benzaphenon resembling the benzodiazepines in its pharmacological action[1]. The effects of CGP11952 (CGP 11.952), a triazolyl Benzophenone, on cognitive functioning are assessed by means of a computerized neuropsychological battery. In the first study CGP11952 turns out to have a positive effect on information processing speed, perceptual sensitivity and preciseness of responses. Negative effects are found on reaction time. In the second study this latter effect is less clear. A striking result is the less negative effect on memory consolidation under influence of CGP11952 in comparison with other benzodiazepines[2].

[1]. Van Wieringen A, et al. Electroencephalographic findings in antiepileptic drug trials: a review and report of 6 studies. Epilepsy Res. 1987 Jan;1(1):3-15. [2]. Alpherts WC, et al. CGP 11.952: an experimental benzodiazepine derivative. Effects on cognitive functioning in patients with epilepsy. Prog Neuropsychopharmacol Biol Psychiatry. 1987;11(6):673-82.