p32 inhibitor M36 (M36) 是一种 p32 线粒体蛋白小分子抑制剂，可直接与 p32 结合，抑制 p32 与 LyP-1 的结合。
CAS：802555-85-7
分子式：C23H28N8O2
分子量：448.52
纯度：98%
存储：Store at -20°C

Background:

p32 inhibitor M36 (M36) is a p32 mitochondrial protein inhibitor, which binds directly to p32 and inhibits p32 association with LyP-1[1]. p32[1]

p32 Inhibitor M36 inhibits SF188 glioma cells proliferation (IC50 of 77.9 μM in complete media) and is much more potent under low glucose conditions with an IC50 of 7.3 μM[1]. p32 Inhibitor M36 is selective for p32 overexpressing cells[1].p32 Inhibitor M36 is also a potent inhibitor of patient-derived neurospheres with an IC50 of 2.8 μM[1].

[1]. Yenugonda V,et al. A novel small molecule inhibitor of p32 mitochondrial protein overexpressed in glioma. J Transl Med. 2017 Oct 18;15(1):210.