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24α-methyl Cholesterol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
24α-methyl Cholesterol图片
CAS NO:474-62-4
规格:98%
分子量:400.7
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
agonist at liver X receptors (LXR)
CAS:474-62-4
分子式:C28H48O
分子量:400.7
纯度:98%
存储:Store at -20°C

Background:

24α-methyl Cholesterol is an agonist of liver X receptors (LXR).


Liver X receptors (LXRs) are ligand-dependent transcription factors involved in the transcriptional control of lipid metabolism. LXRs function as nuclear cholesterol sensors that are activated by elevated intracellular cholesterol levels in multiple cell types. Activation of LXRs induces the expression of various genes involved in cholesterol absorption, transport, efflux, and excretion. In addition to their function in lipid metabolism, LXRs have also been found to modulate immune and inflammatory responses in macrophages. LXRα is highly expressed in the liver and at lower levels in the adrenal glands, adipose, intestine, lung, macrophages, and kidney, and LXRβ is ubiquitously expressed [2].


24α-methyl Cholesterol was a phytosterol found in vegetables, nuts, fruits, and seeds that competitively inhibited the absorption of intestinal cholesterol and decreased the transcription of genes important for cholesterol metabolism [3]. 24α-methyl Cholesterol acted as an agonist at liver X receptors (LXR) and suppressed the proliferation of prostate and breast cancer cells [1].


参考文献:
[1] Chuu C P, Kokontis J M, Hiipakka R A, et al.  Modulation of liver X receptor signaling as novel therapy for prostate cancer[J]. Journal of biomedical science, 2007, 14(5): 543-553.
[2] Zelcer N, Tontonoz P.  Liver X receptors as integrators of metabolic and inflammatory signaling[J]. The Journal of clinical investigation, 2006, 116(3): 607-614.
[3] Segura R, Javierre C, Lizarraga M A, et al.  Other relevant components of nuts: phytosterols, folate and minerals[J]. British Journal of Nutrition, 2006, 96(S2): S36-S44.