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GSK199(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK199(hydrochloride)图片
CAS NO:1549811-53-1
规格:98%
分子量:469
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议
10mg电议

产品介绍
Protein arginine deiminase 4 (PAD4) mediates the transformation of protein arginine into citrulline.
CAS:1549811-53-1
分子式:C24H28N6O2.HCl
分子量:469
纯度:98%
存储:Store at -20°C

Background:

Protein arginine deiminase 4 (PAD4) mediates the transformation of protein arginine into citrulline. Citrullination of proteins has normal roles in gene regulation and pathological roles in immunological and inflammatory diseases. GSK199 is a reversible inhibitor of PAD4 (IC50 = 200 nM) that binds to the low-calcium form of the enzyme and is selective for PAD4 over PAD1-3.It is less potent than the related PAD4 inhibitor GSK484 , which demonstrates an IC50 value of 50 nM. GSK199 can inhibit the citrullination of PAD4 target proteins and diminish the formation of neutrophil extracellular traps in mouse neutrophils.