(+)-Cloprostenol是前列腺素F2α的类似物，为选择性的prostaglandinreceptor激动剂。
CAS：54276-21-0
分子式：C22H29ClO6
分子量：424.92
纯度：98%
存储：Store at -20°C

Background:

(+)-Cloprostenol is a prostaglandin F2α (PGF2α) analogue, and shows selective agonistic activity at the prostaglandin receptor.

D-Cloprostenol and PGF2 alpha are equipotent, about 150 times more potent than dl-cloprostenol (P< 0.05) and approximately 280 times more potent than PGE1 in inhibiting [3H]PGF2 alpha binding to corpus luteum cell membranes. However, d-cloprostenol and PGF2 alpha are about 10 times more potent than dl-cloprostenol and approximately 95 times more potent than PGE1 in myometrial cell membranes[2].

D-cloprostenol (15 g per head) is the lowest dose that consistently achieves abortion; D-cloprostenol causes mild adverse effects including salivation, defecation and hyperventilation in bitches weighing less than 10 kg. Intra-vesicle administration of a single low dose of d-cloprostenol is a safe and successful technique to induce abortion in the bitch[1].

[1]. Manca R, et al. Intra-vesicle administration of D-cloprostenol for induction of abortion in mid-gestation bitches. Anim Reprod Sci. 2008 Jun;106(1-2):133-42. Epub 2007 Apr 21. [2]. Re G, et al. Specific binding of dl-cloprostenol and d-cloprostenol to PGF2 alpha receptors in bovine corpus luteum and myometrial cell membranes. J Vet Pharmacol Ther. 1994 Dec;17(6):455-8.