BI689648是一种新型的，高选择性醛固酮合酶抑制剂，能抑制CYP11B1和CYP11B2，其IC50值分别为310和2.1nM。
CAS：1633009-87-6
分子式：C16H18N4O2
分子量：298.34
纯度：98%
存储：Store at -20°C

Background:

BI 689648 is a novel, highly selective aldosterone synthase inhibitor which can inhibit CYP11B1 and CYP11B2 with IC50s of 310 and 2.1 nM, respectively.

Compare with the FADs and LCI699, BI 689648 is highly selective in vitro, providing an IC50 for CYP11B2 of 2.1 nM and a selectivity factor of 149 over CYP11B1. FAD286, by comparison, shows a similar IC50 for CYP11B2 (2.5 nM); however, its greater potency against CYP11B1 (94 nM) results in a comparatively modest selectivity factor of 38, approximately 4-fold less than BI 689648[1].

After oral administration in cyno monkeys, BI 689648 (5 mg/kg) exhibits a peak plasma concentration of