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4,4'-Dimethoxybenzil(p-Anisil)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
4,4'-Dimethoxybenzil(p-Anisil)图片
CAS NO:1226-42-2
包装:1g
规格:98%
市场价:490元
分子量:270.28

产品介绍
4,4'-Dimethoxybenzil是一种人肠胃羧基酯酶(hCECE)抑制剂,Ki为70nM。
CAS:1226-42-2
分子式:C16H14O4
分子量:270.28
纯度:98%
存储:Store at -20°C

Background:

4,4’-Dimethoxybenzil is a human intestinal carboxyl esterase (hiCE) inhibitor with Ki of 70 nM.


By reducing irinotecaninduced diarrhea, hiCE inhibitors (e.g., 4,4’-Dimethoxybenzil, Compound 8) can improve the anti-cancer efficacy of irinotecan. To find effective hiCE inhibitors, a new virtual screening protocol that combines pharmacophore models derived from the hiCE structure and its ligands has been proposed[1].



[1]. GuoDong Zhang, et al. Predicting hiCE inhibitors based upon pharmacophore models derived from the receptor and its ligands. Science China Chemistry