BT-13是有效的、胶质细胞源性神经营养因子(GDNF)受体RET的选择性激动剂(独立于GDNF配体发挥作用)，促进体外感觉神经元神经突生长，减轻大鼠神经病变的发生。
CAS：924537-98-4
分子式：C23H27F4N3O4S
分子量：517.54
纯度：98%
存储：Store at -20°C

Background:

BT-13 is a potent and selective glial cell line-derived neurotrophic factor (GDNF) receptor RET agonist independently of GFLs, promoting neurite growth from sensory neurons in vitro and attenuates experimental neuropathy in the Rat[1]. GDNF receptor RET[1].

BT-13 stimulates phosphorylation of RET, as well as RET-dependent intracellular signaling, but activated neither NGF receptor TrkA nor BDNF receptor TrkB nor intracellular signaling in the absence of RET[1].

BT-13 (20 and 25mg/kg in rats induced by ligation of left L5 and L6 spinal nerves) has a slight antinociceptive/antihyperalgesic effect and protected DRG neurons in rats with surgery-induced neuropathy[1]. Animal Model: Rats induced by ligation of left L5 and L6 spinal nerves[1].

[1]. Sidorova YA, et al. A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat. Front Pharmacol. 2017 Jun 21;8:365.