SHR1653是强效的、选择性的、能透过大脑的催产素受体 (OTR) 的拮抗剂，对hOTR 的 IC50 值为 15 nM。
CAS：2231770-73-1
分子式：C21H21ClFN5O2
分子量：429.88
纯度：98%
存储：Store at -20°C

Background:

SHR1653 is a highly potent, selective and brain penetrated oxytocin receptor (OTR) antagonist, with an IC50 of 15 nM for hOTR[1]. IC50: 15 nM (hOTR)[1].

[1]. Li X, et al. Discovery of SHR1653, a Highly Potent and Selective OTR Antagonist with Improved Blood-Brain Barrier Penetration. ACS Med Chem Lett. 2019 May 29;10(6):996-1001.