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3β-hydroxy-5-Cholestenoic Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
3β-hydroxy-5-Cholestenoic Acid图片
CAS NO:6561-58-6
规格:98%
分子量:416.6
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
3β-hydroxy-5-Cholestenoic acid is an active metabolite of cholesterol formed when cholesterol is metabolized by the cytochrome P450 (CYP) isomer CYP27A1.
CAS:6561-58-6
分子式:C27H44O3
分子量:416.6
纯度:98%
存储:Store at -20°C

Background:

3β-hydroxy-5-Cholestenoic acid is an active metabolite of cholesterol formed when cholesterol is metabolized by the cytochrome P450 (CYP) isomer CYP27A1. 3β-hydroxy-5-Cholestenoic acid is a modulator of γ-secretase that decreases amyloid β (1-42) peptide (Aβ42; EC50 = 250 nM) and increases Aβ38 levels with no effect on total Aβ in CHO2B7 cells. It decreases endogenous murine Aβ42 production by 60 and 75% in mouse postnatal neuron-glia cultures at concentrations of 3 and 10 μM, respectively.