INVIVO-6983, formerly known as Autophagy inhibitor 6k, is a autophagy inhibitor. INVIVO-6983 has CAS#1227476-98-3. The last 4 digital is used in its name. INVIVO-6983 disrupts the dynamics of actin cytoskeleton in human melanoma cells, affecting processes essential for the maintenance and expansion of tumours such as cell adhesion, motility, proliferation, vesicular transport, and autophagic flux. Inhibition of autophagy by INVIVO-6983 increased the sensitivity of melanoma cells to metabolic stress induced by rotenone or nutrient starvation and potentiated the anti-proliferative activity of small molecule multikinase inhibitor sorafenib. References: Páchniková G, Uldrijan S, Imramovsky A, Krystof V, Slaninová I. Substituted 2-hydroxy-N-(arylalkyl)benzamide sensitizes cancer cells to metabolic stress by disrupting actin cytoskeleton and inhibiting autophagic flux. Toxicol In Vitro. 2016 Dec;37:70-78. doi: 10.1016/j.tiv.2016.09.006. Epub 2016 Sep 7. PubMed PMID: 27612957.

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CAS：1227476-98-3