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CLIP 86-100
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:648881-58-7
规格:98%
分子量:1674.1
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
CLIP (86-100) 是 Ⅱ 类相关不变链肽 (CLIP) 的 86-100 个氨基酸片段。CLIP 是一个小的自体肽,也是位于 HLA-II 抗原结合区的固定链的裂解产物。通过与 Ⅱ 类肽结合位点的相互作用,CLIP 在 MHC Ⅱ 类 alphabetaIi 复合体的组装和转运中起着关键作用。
CAS:648881-58-7
分子式:C72H128N20O19S3
分子量:1674.1
纯度:98%
存储:Store at -20°C

Background:

CLIP (86-100) is amino acids 86 to 100 fragment of class II-associated invariant chain peptide (CLIP). CLIP is a small self-peptide and cleavage product of the invariant chain that resides in the HLA-II antigen binding groove and is believed to play a critical role in the assembly and transport of MHC class II alphabetaIi complexes through its interaction with the class II peptide-binding site[1].




[1]. van Luijn MM, et al. Class II-associated invariant chain peptide as predictive immune marker in minimal residual disease in acute myeloid leukemia. Oncoimmunology. 2015 Jan 7;3(12):e941737. eCollection 2014 Dec. [2]. Thayer WP, et al. Class II-associated invariant chain peptide-independent binding of invariant chain to class II MHC molecules. J Immunol. 1999 Feb 1;162(3):1502-9.