CYP17-IN-1 (compound 9c) 是一种有效的，具有口服活性的 CYP17 的抑制剂，对大鼠和人 CYP17 的 IC50 值为 15.8 和 20.1 nM。
CAS：2093317-51-0
分子式：C18H17FN2S
分子量：312.4
纯度：98%
存储：Store at -20°C

Background:

CYP17-IN-1 (compound 9c) is a potent and orally active CYP17 inhibitor against rat and human CYP17 with IC50s of 15.8 and 20.1 nM[1]. IC50: 15.8 nM (Rat CYP17), 20.1 nM (Human CYP17)[1]

CYP17-IN-1 (compound 9c) exhibits an IC50 value of 8.5 µM against CYP3A4[1].

CYP17-IN-1 (compound 9c) reduces plasma testosterone level in a dose-dependent manner in Sprague-Dawley rats[1].

[1]. Wang M, et al. Discovery of novel 1,2,3,4-tetrahydrobenzo[4, 5]thieno[2, 3-c]pyridine derivatives as potent and selective CYP17 inhibitors. Eur J Med Chem. 2017 May 26;132:157-172.