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PF-03654746
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF-03654746图片
CAS NO:935840-31-6
规格:98%
分子量:322.39
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
PF-03654746 是一种有效的选择性 H3 histamine H3 receptor 受体拮抗剂,具有高脑渗透性。PF-03654746 可减少过敏原引起的鼻腔症状,可能是进一步探索过敏性鼻炎的新型治疗策略。PF-03654746 提高阿尔茨海默病 (AD) 的认知功效和改善疾病的效果。
CAS:935840-31-6
分子式:C18H24F2N2O
分子量:322.39
纯度:98%
存储:Store at -20°C

Background:

PF-03654746 is a potent and selective histamine H3 receptor antagonist with high brain penetration.PF-03654746 reduces allergen-induced nasal symptoms, might be a novel therapeutic strategy to further explore allergic rhinitis[1].PF-03654746 improves cognitive efficacy and disease-modifying effects in Alzheimer’s disease (AD)[2].




[1]. Stokes JR, et al. The effects of an H3 receptor antagonist (PF-03654746) with fexofenadine on reducing allergic rhinitis symptoms. J Allergy Clin Immunol. 2012 Feb;129(2):409-12, 412.e1-2. [2]. Brioni JD, et al. Discovery of histamine H3 antagonists for the treatment of cognitive disorders and Alzheimer’s disease. J Pharmacol Exp Ther. 2011 Jan;336(1):38-46.