Extracted?from?Aristolochia debilis;Store?the?product?in?sealed,?cool?and?dry?condition
CAS：313-67-7
分子式：C17H11NO7
分子量：341.27
纯度：98%
存储：Store at -20°C

Background:

Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines[1].

Aristolochic acid A (150, 200 μM, 24?hours) inhibits the cell viabilities of kidney cells HEK293 and HK-2[1].Aristolochic acid A (100, 200 μM, 24?hours) causes a concentration-dependent decrease in bladder cancer-associated protein (BLCAP) mRNA levels in kidney cells (HEK 293 and HK-2) , and bladder cancer cell line (HT-1376)[1].Aristolochic acid A (100, 200 μM, 24?hours) weakens the BLCAP protein signals in a dose-dependent manner in both HEK293 and HT-1376 cells[1].

参考文献:
[1]. Huang YT, et al. Aristolochic acid I interferes with the expression of BLCAP tumor suppressor gene in human cells. Toxicol Lett. 2018 Jul;291:129-137.