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Bethanechol(Carbamyl-β-methylcholine)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bethanechol(Carbamyl-β-methylcholine)图片
CAS NO:674-38-4
包装:1g
规格:98%
市场价:490元
分子量:161.22

产品介绍
Bethanechol是一种副交感神经胆碱氨基甲酸酯,选择性地刺激毒蕈碱受体,而对烟碱受体没有影响。
CAS:674-38-4
分子式:C7H17N2O2
分子量:161.22
纯度:98%
存储:Store at -20°C

Background:

Bethanechol is a parasympathomimetic choline carbamate that selectively stimulates muscarinic receptors without any effect on nicotinic receptors.Target: muscarinic receptorHyoscine butylbromide concentration dependently reduced muscle contractions, calcium mobilization, and epithelial secretion induced by the muscarinic agonist bethanechol with IC50 values of 429, 121, and 224 nmol L(-1), respectively.[2] Bethanechol presentes significantly improve of salivary parameters. Bethanechol is effective in decreasing the salivary gland damage.[3] Cerebral malakoplakia is a very rare chronic inflammatory disease. Treatment with antibiotic Bethanechol improves symptoms in association with a decrease in the abnormal calcification and enhancement.[4]




[1]. Bethanechol [2]. Krueger D, et al. Effect of hyoscine butylbromide (Buscopan) on cholinergic pathways in the human intestine. Neurogastroenterol Motil. 2013 Aug;25(8):e530-9. [3]. Jaguar GC, et al. Double blind randomized prospective trial of bethanechol in the prevention of radiation-induced salivary gland dysfunction in head and neck cancer patients. Radiother Oncol. 2015 May;115(2):253-256. [4]. Fudaba H, et al. An adult case of cerebral malakoplakia successfully cured by treatment with antibiotics, bethanechol and ascorbic acid. J Neurol Sci. 2014 Jul 15;342(1-2):192-196.