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HMR 1556
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
HMR 1556图片
CAS NO:223749-46-0
包装:5mg
规格:98%
市场价:1753元
分子量:411.44

产品介绍
HMR1556,色氨醇衍生物,是一种IKs阻滞剂,在犬和豚鼠的左心室肌细胞中的IC50值分别为10.5nM、34nM。
CAS:223749-46-0
分子式:C17H24F3NO5S
分子量:411.44
纯度:98%
存储:Store at -20°C

Background:

HMR 1556, a chromanol derivative, is a IKs blocker with IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively[1][2]. IC50: 10.5 nM (IKs in canine left ventricular myocytes), 34 nM (IKs in guinea pig left ventricular myocytes)[1]


HMR 1556 inhibits Ito, ICa,L and IKr with IC50s of 33.9 μM, 27.5 μM, 12.6 μM in canine left ventricular myocytes, respectively[1].



[1]. Thomas GP, et al. HMR 1556, a potent and selective blocker of slowly activating delayed rectifier potassium current. J Cardiovasc Pharmacol. 2003 Jan;41(1):140-7. [2]. Gerlach U,et al. Synthesis and activity of novel and selective I(Ks)-channel blockers. J Med Chem. 2001 Nov 8;44(23):3831-7.