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ML-210
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ML-210图片
CAS NO:1360705-96-9
规格:98%
分子量:475.3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
ML-210 is a small molecule that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 71 and 272 nM in HRASG12V-expressing and non-expressing BJeH cells, respectively).
CAS:1360705-96-9
分子式:C22H20Cl2N4O4
分子量:475.3
纯度:98%
存储:Store at -20°C

Background:

ML-210 is an inhibitor of glutathione peroxidase 4 (GPX4).[1] It reduces viability of mesenchymal-state KP4 cells, an effect that can be blocked by the arachidonic acid lipoxygenase inhibitors PD 146176 and zileuton. It is also selectively lethal to mutant RAS oncogene-expressing cells (IC50s = 71 and 272 nM in HRASG12V-expressing and wild-type RAS-expressing BJeH cells, respectively).[2]


Reference:
[1]. Viswanathan, V.S., Ryan, M.J., Dhruv, H.D., et al. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature 547(7664), 453-457 (2017).
[2]. We?wer, M., Bittker, J.A., Lewis, T.A., et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorg. Med. Chem. Lett. 22(4), 1822-1826 (2012).