ME-3221 is an angiotensin type 1 receptor antagonist potentially for the treatment of hypertension. ME3221 prevents hypertensive complications in aged stroke-prone spontaneously hypertensive rats. n rats and marmosets, ME3221 antagonized angiotensin II-induced pressor responses, but did not affect bradykinin-induced depressor responses. ME3221 lowered the blood pressure in renal hypertensive rats and spontaneously hypertensive rats (SHR), and its ED25 value was 3 times that of losartan. References: Kawano K, Fujishima K, Nagura J, Yasuda S, Shinki, Hachisu M, Konno F. Nonpeptide angiotensin II receptor antagonist recognizes inter-species differences in angiotensin AT1 receptors. Eur J Pharmacol. 1998 Sep 11;357(1):33-9. PubMed PMID: 9788771.

纯度：≥98%

CAS：139958-16-0