PH-002是一种抑制载脂蛋白(apo)E4神经内分子相互作用的抑制剂，其IC50(FRET)值为116nM。
CAS：1311174-68-1
分子式：C27H33N5O4
分子量：491.58
纯度：98%
存储：Store at -20°C

Background:

PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells that could rescue impairments of mitochondrial motility and neurite outgrowth.

PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells, with an IC50 of 116 nM in FRET[1].

PH-002 is also shown to increase COX1 levels in primary neurons from NSE-apoE4 transgenic mouse cortex and hippocampus. After 4 days of treatment with PH-002 (200 nM), COX1 levels are increased by