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Salsolidine(6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Salsolidine(6,7-Dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline)图片
CAS NO:5784-74-7
规格:98%
分子量:207.27
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议

产品介绍
Salsolidine是一种四氢异喹啉类生物碱,能够立体选择竞争性的抑制MAOA的活性。
CAS:5784-74-7
分子式:C12H17NO2
分子量:207.27
纯度:98%
存储:Store at -20°C

Background:

Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor.


Salsolidine is a tetrahydroisoquinoline alkaloid, acts as a stereoselective competitive MAO A inhibitor. The R-salsolidine is more active against MAO A than S-salsolidine (Ki, 6 μM and 186 μM)[1]. Salsolidine weakly inhibits the binding of δ-receptor, with a Ki of >100 μM[2]. Salsolidine has the potential of inhibiting Acetylcholinestearse and butyrylcholinesterase[3].



[1]. Bembenek ME, et al. Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines. J Med Chem. 1990 Jan;33(1):147-52. [2]. Airaksinen MM, et al. Binding of beta-carbolines and tetrahydroisoquinolines by opiate receptors of the delta-type. Acta Pharmacol Toxicol (Copenh). 1984 Nov;55(5):380-5. [3]. Tundis R, et al. A potential role of alkaloid extracts from Salsola species (Chenopodiaceae) in the treatment of Alzheimer’s disease. J Enzyme Inhib Med Chem. 2009 Jun;24(3):818-24.