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3,4-Dimethoxycinnamic acid(O-Methylferulic acid)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
3,4-Dimethoxycinnamic acid(O-Methylferulic acid)图片
CAS NO:2316-26-9
包装:100mg
规格:98%
市场价:445元
分子量:208.21

产品介绍
3,4-Dimethoxycinnamicacid(O-Methylferulicacid)是从Securidacainappendiculata中提取和纯化的单体。3,4-Dimethoxycinnamicacid通过ROS介导的信号途径对L-02细胞发挥抗凋亡作用。
CAS:2316-26-9
分子式:C11H12O4
分子量:208.21
纯度:98%
存储:Store at -20°C

Background:

3,4-Dimethoxycinnamic acid (O-Methylferulic acid) is a monomer extracted and purified from Securidaca inappendiculata Hassk. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway[1]. Anti-apoptotic effects[1].


3,4-Dimethoxycinnamic acid (Methyl ferulic acid; 25, 50 and 100 µM) attenuates the ethanol-induced apoptosis of ethanolexposed L-02 cells[1]. 3,4-Dimethoxycinnamic acid (25, 50 and 100 µM) inhibits the expression levels of Nox4 and p22phox in L-02 cells[1]. 3,4-Dimethoxycinnamic acid (25, 50 and 100 µM) treatment attenuates ethanol-induced MAPK phosphorylation in L-02 cells[1].3,4-Dimethoxycinnamic acid decreases the expression levels of superoxide dismutase, catalase and phospholipid hydroperoxide gluthione peroxidase, and downregulates the levels of Bax/Bcl-2 and the cleaved forms of caspase-3 in a dose- and time-dependent manner[1].



[1]. Li L, et al. Methyl ferulic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signalingpathway. Int J Oncol. 2018 Jul;53(1):225-236.